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Updated: June 1, 2025
Sooner or later, however, the left ventricle will become weakened, especially when there is arteriosclerosis or other hypertension, and chronic endocarditis and fatty degeneration result. If the left ventricle becomes sufficiently weakened or dilated, the same damming back of the blood through the lungs and right heart occurs, and more or less serious signs of broken compensation develop.
Therefore, nicotin becomes a decided cause of hypertension and arteriosclerosis. Thayer found that heavy work is the cause of about two thirds of all cases of arteriosclerosis, and one of the functions of the suprarenals is to destroy the waste products of muscular activity; hence these glands, in these cases, are hypersecreting.
Together with oxalic acid, it is responsible for arteriosclerosis, arthritic rheumatism and the formation of calculi. Dr. Haig of London has done excellent work in the investigation of uric-acid poisoning, but he becomes one-sided when he makes uric acid the scapegoat for all disease conditions originating in the organism.
Although the arterial pressure has been high before arteriosclerosis developed, and may remain high for some time in the arteries, unless the heart fails, the distal peripheral pressure, as in the fingers and toes, may be poor in spite of the high blood pressure. When the left heart begins to fail, pendent edema readily occurs.
Calcium metabolisim in arteriosclerosis and in softening of the bones is not well understood. Patients with this lesion are seriously handicapped when any congestion of the lungs occurs, such as pneumonia, pleurisy, or even bronchitis. Asthma is especially serious in these cases, and these patients rarely live to old age.
The main danger, however, with a heart with this lesion, occurring coincidently with arteriosclerosis, is a progressive chronic myocarditis. Tricuspid insufficiency, except as rarely found in the fetus, is generally due to a relative insufficiency rather than to an actual disease of the tricuspid valve. In other words, if the right ventricle dilates the valve may be insufficient.
"Of course," opened Kennedy, "you know that investigation has shown that you were right in your diagnosis of the trouble with Marchant. Was it arteriosclerosis for which you were treating him?" "It would be unprofessional to discuss it," hastily parried Karatoff, "but, since Mr. Marchant is now dead, I think I may say that it was.
As a beverage, when constantly used, it is liable to cause obesity, gastric indigestion, arteriosclerosis, myocardial degeneration, chronic nephritis and cirrhosis of the liver. Its first action is undoubtedly as a food, if not too large amounts are taken, and therefore it is a protector of other food, especially of fat and starch.
Lead may be a cause of increased blood pressure, and diabetics occasionally have a high pressure, although more frequently there is a lowering of blood pressure in diabetes. Richman believes that syphilis is the most common cause of hypertension and arteriosclerosis without renal disease. When arteriosclerosis and renal disease are combined, of course the highest systolic readings occur.
The blood pressure may be sufficient, or even increased if arteriosclerosis is present, although the rise of the sphygmograph tracing is not so high as normal. If the pressure in the aorta is sufficient from the amount of blood forced into it, the coronary arteries receive enough blood to keep up the nutrition of the heart muscle.
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