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Updated: June 10, 2025
It may often be necessary to administer strychnin, although if the patient is greatly excited it should be withheld as long as possible. For the same reason camphor, coffee and other cardiac stimulants which cause cerebral excitation should be withheld. If the patient is in alcoholic coma, the pulse is generally slow, although it may be of low pressure unless the patient is otherwise diseased.
Strychnin in small doses may be needed, but in these patients, who are generally nervous, it is usually better not to give it. One of the best sedatives to a heart that is irregular in its action and not acting strongly is lime; a good way to administer it is in the form of calcium lactate, and the dose is 0.3 gm.
It has no action on the vasomotor center. They found that strychnin in large doses may stimulate the vasomotor center moderately, but usually it did not act on this center unless the patient was asphyxiated; then it acted intensely.
Atropin in a dose of 1/150 grain, and strychnin in a dose of 1/40 or 1/30 grain are valuable aids in stimulating the circulation under these conditions. The atropin should not be repeated. The strychnin may be repeated in three, four or five hours, depending on the size of the previous close.
Cardiac Tonics: Digiralis, strophanthus, caffein, strychnin. 2. Cardiac Stimulants: Camphor, alcohol, ammonia. 3. Vasodilators: Nitrites, iodids, thyroid extract. 4. Cardiac Nutritives: Iron, calcium. 5. Cardiac Emergency Drugs: Ergot, suprarenal active principle, pituitary active principle, atropin, morphin, and also some of the drugs already mentioned.
It had followed an attack of whooping-cough, and was finally cured apparently by the administration of strychnin. Cowan speaks of a shoemaker of twenty-two who experienced an attack of constant singultus for a week, and then intermittent attacks for six years. Cowan also mentions instances of prolonged hiccough related by Heberden, Good, Hoffman, and Wartmouth.
Skinner noticed the occurrence of a scarlatiniform eruption in a woman after the dose of 1/165 grain of strychnin, which, however, disappeared with the discontinuance of the drug. There was a man in London in 1865 who died in twenty minute's after the ingestion of 1/2 grain of strychnin. Wood speaks of a case in which the administration of 1/100 grain killed a child three and one-half months old.
H-ion concentration tests were made after the application of the adequate stimuli by which the function of the kinetic organs had been determined, and we studied also the effect upon the acidity of the blood of strychnin convulsions after destruction of the medulla; of deep narcotization with morphin before anesthesia; of deep narcotization with morphin after the H-ion concentration had already been increased by fear, by anger, by exertion, by injury under anesthesia, or by anesthesia alone.
In Graves' disease the brain-cells show marked changes which are apparently the same as those produced by overwork, by the emotions, and by strychnin. In the postmortem examination of one advanced case it was found that a large number of brain-cells were disintegrated beyond the power of recuperation, even had the patient lived.
If acute myocarditis is believed or known to be present, cardiac tonics such as digitalis should not be given; large doses of strychnin should not be given; vasocontractors such as ergot should not be given; large amounts of food or large bulks of liquid should not be taken into the stomach at one time; in fact, unless there is some special indication, the twenty-four hour amount of fluid should be diminished.
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