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Updated: June 9, 2025
As the peasantry of England before Jenner had known of the curative value of cow-pox over small-pox, so the peasant women of Poland had learned that the annoying skin disease from which they suffered was caused by an almost invisible insect, and, furthermore, had acquired the trick of dislodging the pestiferous little creature with the point of a needle.
From the fact that certain persons, usually milkmaids, who had suffered from cow-pox seemed to be immuned to small-pox, it would seem a very simple process of deduction to discover that cow-pox inoculation was the solution of the problem of preventing the disease.
The cow-pox ran its ordinary course without any injurious effect, and the boy was afterward inoculated for the small-pox, happily in vain. The protection was complete; and Jenner thenceforward pursued his experiments with redoubled ardor.
As the cases of inoculation multiply, I am more and more convinced of the extreme mildness of the symptoms arising merely from the primary action of the virus on the constitution, and that those symptoms which, as in the accidental cow-pox, affect the patient with severity, are entirely secondary, excited by the irritating processes of inflammation and ulceration; and it appears to me that this singular virus possesses an irritating quality of a peculiar kind, but as a single cow-pox pustule is all that is necessary to render the variolous virus ineffectual, and as we possess the means of allaying the irritation, should any arise, it becomes of little or no consequence.
There are also several kinds of spurious cow-pox to which the cow is subject, and which would be likely to be mistaken for the real lymph. Again, if even the genuine matter were not taken from the cow exactly at the proper time, it would he deprived of its protecting power. At what age do you recommend an infant to be first vaccinated?
"I omitted mentioning another great advantage that now occurs to me in the inoculated cow-pox; I mean, the safety with which pregnant women may have the disease communicated to them. I have inoculated a great number of females in that situation, and never observed their cases to differ in any respect from those of my other patients.
It may be here mentioned that it has been long known among the illiterate cow-herds in the mountains of Peru, all either native Peruvians or Negroes, that a disease of the hands which they are liable to be infected with on handling diseased cow udders, the cow-pox, effectually arms all who have been subjected to it against the infection of the small-pox.
It is singular to observe that the cow pox virus, although it renders the constitution unsusceptible of the variolous, should nevertheless, leave it unchanged with respect to its own action. Elizabeth Wynne, who had the cow-pox in the year 1759, was inoculated with variolous matter, without effect, in the year 1797, and again caught the cow-pox in the year 1798.
I mentioned the circumstance in the presence of the officers, at the time expressing my doubts if it were not smallpox, and was not a little surprised when I was told by the Colonel that he had frequently heard you mention the cow-pox as a disease endemial to Gloucestershire, and that if a person were ever affected by it, you supposed him afterwards secure from the smallpox.
The spring of the year 1797, which I intended particularly to have devoted to the completion of this investigation, proved, from its dryness, remarkably adverse to my wishes;-for it frequently happens, while the farmers' horses are exposed to the cold rains which fall at that season, that their heels become diseased, and no cow-pox then appeared in the neighbourhood.
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