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Updated: June 11, 2025
Wolfer has been successful in transplanting the mucous membranes of frogs, rabbits, and pigeons to a portion of mucous membrane previously occupied by cicatricial tissue, and was the first to show that on mucous surfaces, mucous membrane remains mucous membrane, but when transplanted to skin, it becomes skin.
In its growth it gradually obliterates the capillaries, until at the end of two, three, or four weeks both vessels and cells have almost entirely disappeared, and the original wound is occupied by cicatricial tissue. In course of time this tissue becomes consolidated, and the cicatrix undergoes a certain amount of contraction cicatricial contraction. Healing of Epidermis.
At fourteen she was burned over her breasts by running against a shovelful of hot coals, and several months later small tumors appeared, which never suppurated. When a young girl a tumor was removed from the front of her neck by operation, and cicatricial tumors then spread like a band encircling one-half her neck. There were keloids over her scapulae, which followed the application of blisters.
Secondary hæmorrhage as a result of infective processes ensuing in the wound. Loss of muscle or tendon, interfering with motion. Cicatricial contraction. Gangrene, which may follow occlusion of main vessels, or virulent infective processes. It is not uncommon to have particles of carbon embedded in the tissues after lacerated wounds, leaving unsightly, pigmented scars.
When there is actual destruction of tissue and ulceration the so-called "lupus excedens" or "ulcerans" healing is attended with cicatricial contraction, which may cause unsightly deformity. When the cheek is affected, the lower eyelid may be drawn down and everted; when the lips are affected, the mouth may be distorted or seriously diminished in size.
The exudate on the surfaces causes them to adhere, capillary loops pass from one to the other, and their final fusion takes place by the further development of granulation and cicatricial tissue. Reunion of Parts entirely Separated from the Body.
The deformity resulting from these necessarily heroic measures is not so great as might be expected, and can be further diminished by plastic operations, which should be undertaken before cicatricial contraction has occurred.
There is no enlargement of adjacent glands, and but little inflammatory reaction in the surrounding tissues; nor is there any marked constitutional disturbance. Recovery is often followed by cicatricial contraction leading to deformity of the face. The treatment consists in destroying the original papule by the actual cautery, acid nitrate of mercury, or pure carbolic acid.
From this time the man speedily failed, and after his death there were cicatricial signs found, particularly on the wall of the left ventricle, together with patency of the interventricular septum, with signs of cicatrization about this rent. At the side of the left ventricle the rent was twice as large and lined with cicutricial tissue.
After fractures of costal cartilage or of the cartilages of the larynx the cicatricial tissue may be ultimately replaced by bone. Tendons. When a tendon is divided, for example by subcutaneous tenotomy, the end nearer the muscle fibres is drawn away from the other, leaving a gap which is speedily filled by blood-clot.
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