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Updated: June 11, 2025
In course of time the epithelium thickens, and as the granulation tissue is slowly replaced by young cicatricial tissue, which has a peculiar tendency to contract and so to obliterate the blood vessels in it, the scar that is left becomes smooth, pale, and depressed.
More complex structures, on the other hand, such as secreting glands, muscle, and the tissues of the central nervous system, are but imperfectly restored, simple cicatricial connective tissue taking the place of what has been lost or destroyed.
The tube of radium is applied at intervals to different parts of the nævus, the duration and frequency of the applications varying with the strength of the emanations and the reaction produced. The object aimed at is to induce obliteration of the nævoid tissue by cicatricial contraction without destroying the overlying skin.
Under this scab the formation of granulation tissue, its transformation into cicatricial tissue, and the growth of epithelium on the surface, go on until in the course of time the crust separates, leaving a scar. Healing by Blood-clot.
As a result of the subsequent contraction of the cicatricial tissue, the scar is usually depressed below the level of the surrounding skin surface. If an abscess is prevented from healing for example, by the presence of a foreign body or a piece of necrosed bone a sinus results, and from it pus escapes until the foreign body is removed.
In the kidney also, repair mainly takes place by cicatricial tissue, and although a few collecting tubules may be reformed, no regeneration of secreting tissue takes place.
Thiersch therefore recommends that for the prevention of cicatricial contraction, the grafting be performed with large strips of skin. Harte gives illustrations of a case of extensive skin-grafting on the thigh from six inches above the great trochanter well over the median line anteriorly and over the buttock.
When an articular cartilage is divided by incision or by being implicated in a fracture involving the articular end of a bone, it is repaired by ordinary cicatricial fibrous tissue derived from the proliferating cells of the perichondrium. Cartilage being a non-vascular tissue, the reparative process goes on slowly, and it may be many weeks before it is complete.
It is believed that this functional heart trouble is caused by the increased connective-tissue fibers of the sexual organs acting in some unknown way on the terminal fibers of the sympathetic; and it is not infrequently due to the formation of scar tissue at the seat of a cervical laceration, and has often been promptly and permanently relieved by removing the cicatricial tissue and suturing the wound.
Hollow viscera, like the œsophagus and urinary bladder, in so far as they are not covered by peritoneum, heal less rapidly. Nerve Tissues. There is no trustworthy evidence that regeneration of the tissues of the brain or spinal cord in man ever takes place. Any loss of substance is replaced by cicatricial tissue.
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