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Updated: June 16, 2025
According to the early researches we could not discover any of these relationships which only become evident when we come to study the new discoveries which have been made in connection with the tropines, to which class belong both duboisine and hyoscyamine, which, although differing from atropine, are equally mydriatic in their action. Discovered by Mein in 1831 in the roots of belladonna.
The crystals are then dissolved in alcohol, which, on being poured into water, parts with them in the same form. Hyoscyamine crystallizes in the acicular form, with greater difficulty even than atropine, it also forms less compact crystals. Its fusing point is 149.6 deg. F. I have not yet succeeded in crystallizing any of its more simple salts. The double platinum salt melts at 392 deg.
UTERINE HEMORRHAGES: Take Stypticin tablets according to printed direction on the package. UTERINE TONIC: Helonin, three grains; Caulophyllin, three grains; Macrotin, three grains; Hyoscyamine, three grains. Make twenty pills. Dose: One pill after meals.
The "heavy daturine," of which only a small quantity is obtainable, is far from being a body of definite composition, that is to say, it is a mixture of atropine and hyoscyamine. If we convert the base into a double gold salt we obtain by a single crystallization a dull looking salt, melting at from 275 deg. F. to 280 deg. F., the appearance of which is very different to that of atropine.
In the pure state it forms a viscous mass with a repulsive odor. These researches were repeated by Thibout, Kletinski, Ludwig, Lading, Bucheim, Wagymar, and Renard. Hoehn and Reichardt have recently studied hyoscyamine in a very complete manner. They have obtained the body in the form of warty concretions as soft as wax, and melting at 194 deg.
These characteristics allow us to differentiate atropine and hyoscyamine, the reactions of which are almost identical, as will be seen from the following table, which shows the action of weak solutions of the acids named on the hydrochlorates of the bases: Reagents. Hyoscyamine. Atropine. Picric acid. An oil solidifying Crystalline precipitate. immediately into tabular crystals.
"By means of this," Driscoll declared. "This fluid is henbane that is the commercial name of it known to the profession, however, as hyoscyamus or hyoscyamine. This little implement, I found, in the medicine chest in Miss Ames' bathroom " "No! no!" screamed Aunt Abby. "I never saw it before!" "I don't think you did," said Driscoll, quietly. "But here is a side light on the subject.
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