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Except in large doses, salicylates probably do not depress the heart. In pericarditis it is perhaps well always to administer an alkali in some form unless otherwise contraindicated, whether or not the cause is rheumatism. A diminished alkalinity of the blood would always increase the likelihood of an augmented amount of pericardial or endocardial inflammation.

Therefore when a heart has serious lesions, whether of the myocardium or of the valves, with compensation only sufficient, the action of caffein in any form is contraindicated.

In small puncture wounds the immediate application of a vesicating ointment has given good results, but when infection has taken place to such extent that the animal manifests evidence of intense pain, and lameness is marked and local swelling and hyperesthesia are great, vesication is contraindicated.

This supposition is inadmissible, for it rests on no kind of proof; it is, moreover, contraindicated by the evident fact that the advance in the organic series has been more rapid in recent time than at any stage of the past.

If for any reason morphin is contraindicated, and if pain is not a symptom, the patient's nerves may be quieted and rest may be given by sodium bromid, or by veronal-sodium, the dose of the former being 2 gm.

Of all quickly acting stimulants, none is better than camphor in saturated solution in sterile oil as may be obtained in ampules. Alcohol is absolutely contraindicated in the latter condition. In the former kind of heart attack, vasodilation from a large close of whisky or brandy may be of value.

If the pulse is very weak, the cerebral sedatives more frequently used in delirium tremens, such as chloral, bromids, paraldehyd, etc., are generally contraindicated. A hot foot-bath and an ice-cap on the head sometimes aid in establishing a more general equalization of the circulation.

When alcohol is administered regularly, whether during a fever process or for any other reason, if it causes a dry tongue, cerebral excitement, flushed face and a bounding pulse or if there is the odor of alcohol on the breath, the dose is too large, and alcohol is contraindicated.

The conclusion to be drawn from their experiments is that when there is asphyxia, increased venous pressure, and also a rising blood pressure from the stimulation of carbon dioxid, strychnin is contraindicated. It should be recognized that digitalis very frequently not only does not raise blood pressure, but also may lower it; especially in aortic insufficiency and when there is cyanosis.

On the other hand, if the diastolic is being raised by an increased venous pressure from a failing heart, digitalis, strychnin and caffein may be of benefit in lowering the diastolic as well as raising the systolic. However, if there is a high systolic and a low diastolic pressure, vasodilators are often contraindicated.