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Updated: May 19, 2025
To have very much thyroid and very little pituitary, much adrenal and not enough parathyroid meant a great deal to the Organism as a whole, as well as to the vegetative apparatus. For states of tension and relaxation, activity and inactivity in the nerves and viscera would be determined by these variations in the ratio between the variants.
The parathyroid glands are probably closely concerned in regulating the retention and excretion of salts, and especially of calcium, a circumstance which becomes of significance when we remember how frequently rickety changes, tetany, and other convulsive seizures form part of the clinical picture which we are now considering.
If now, when the muscle begins to lag in its response, and its contractions to decrease, one injects into a vein extracts of thyroid, parathyroid, or adrenal glands, they will immediately reinvigorate the failing contractions. The injections must be made before the fatigue is carried to the point of absolute exhaustion.
Every individual born among the vertebrates, for example, must have a certain definite amount and percentage of pituitary gland, anterior and posterior, pineal, thyroid, parathyroid, thymus, adrenal, pancreas, interstitial and so on. One obtains at once from the contrasts of such figures some idea of the possibilities.
Not long ago these glands were a complete enigma, owing to the fact that they are not provided with excretory ducts. It has just recently been shown that these organs, such as the thyroid, the pituitary, the suprarenal, the parathyroid and the reproductive glands, exercise an all-powerful influence upon the course of individual development or deficiency.
All sorts of tests have related the malady to the phenomena succeeding parathyroid deprivation, and they are now looked upon as aspects of it. Individuals have been reported suffering from an insufficiency of the internal secretion of parathyroids, with a sudden extreme depression, nervousness and restlessness, an inability to sleep or sit still, and a tremulous handwriting.
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