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Updated: June 19, 2025


Within the area thus circumscribed the struggle between the bacteria and the phagocytes takes place, and in the process toxins are formed by the organisms, a certain number of the leucocytes succumb, and, becoming degenerated, set free certain proteolytic enzymes or ferments.

Once she turned the sub-stage mirror a bit to catch the light streaming in the window. Brion stood behind her, fists clenched, forceably controlling his anxiety. "What do you see?" he finally blurted out. "Phagocytes, platelets ... leucocytes ... everything seems normal." Her voice was dull, exhausted, her eyes blinking with fatigue as she stared into the tube.

Within a few hours the peritoneal surfaces are glued together by a thin layer of fibrin and leucocytes, which is speedily organised and replaced by fibrous tissue. Fibrous tissue takes the place of the muscular elements, which are not regenerated. The mucous lining is restored by ingrowth from the margins, and there is evidence that some of the secreting glands may be reproduced.

Changes in the blood vessels then ensue, the arteries becoming dilated and the rate of the current in them being for a time increased active hyperæmia. Coincidently with these changes in the vessels, the leucocytes in the blood of the inflamed part rapidly increase in number, and they become viscous and adhere to the vessel wall, where they may accumulate in large numbers.

The leucocytosis begins soon after the infection manifests itself for example, by shivering, rigor, or rise of temperature. The number of leucocytes rises somewhat rapidly, increases while the condition is progressing, and remains high during the febrile period, but there is no constant correspondence between the number of leucocytes and the height of the temperature.

The arrest of the inflammation and its resolution are accompanied by a fall in the number of leucocytes, while the occurrence of suppuration is attended with a further increase in their number.

I am not interested in the chemicals and the microbes: I leave them to the chumps and noodles, to the blockheads and the muckrakers who are incapable of their own glorious destiny, and unconscious of their own divinity. They tell me there are leucocytes in my blood, and sodium and carbon in my flesh.

When Metchnikoff believed he had discovered that the leucocytes in the blood absorb and digest microbes and thus save man from infection, it seemed as if a ray of clear and simple light had illuminated all the mystery.

In the production of immunity the leucocytes and certain other cells play an important part in virtue of the power they possess of ingesting bacteria and of destroying them by a process of intra-cellular digestion.

They have a structure similar to that of veins, but are more abundantly provided with valves. Along the course of the lymph trunks are the lymph glands, which possess a definite capsule and are composed of a reticulated connective tissue, the spaces of which are packed with leucocytes.

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