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The writings of Lamettrie exhibit the union of Cartesian and English materialism. Lamettrie utilizes the physics of Descartes down to its utmost detail. His l'homme machine is a performance executed on the model of the animal machine of Descartes.

The confidence of the supporters of the mechanical theories of earlier days, from Descartes onward, that animals and the bodies of men were machines, mechanical automata, down to the mechanical theories of Lamettrie and Holbach, of l’homme machine, and of the système de la nature, was at least as great as, probably greater than, that of the supporters of the modern theories.

This school commences with the doctor Leroy, and reaches its acme with the doctor Cabanis, while the doctor Lamettrie is its centre. Descartes was still living when Leroy transferred to the human soul the Cartesian construction of animals, and explained the soul as a mode of the body and ideas as mechanical movements, similarly to Lamettrie in the eighteenth century.

Gamelin had never denied the existence of God; he was a deist and believed in a Providence that watches over mankind; but, admitting that he could form only a very vague conception of the Supreme Being and deeply attached to the principle of freedom of conscience, he was quite ready to allow that right-thinking men might follow the example of Lamettrie, Boulanger, the Baron d'Holbach, Lalande, Helvétius, the citoyen Dupuis, and deny God's existence, on condition they formulated a natural morality and found in themselves the sources of justice and the rules of a virtuous life.

The ancient teachers were inaccessible owing to the length of their works, or the difficulty of the language; but Jouffroy and Damiron initiated them into modern philosophy, and they had authors who dealt with that of the last century. Bouvard derived his arguments from Lamettrie, Locke, and Helvetius; Pécuchet from M. Cousin, Thomas Reid, and Gérando.