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Updated: May 6, 2025
Without any apparent reason the poison of rheumatism habitually attacks one joint on one day, and another joint on another day, and with as little apparent reason it occasionally falls of a sudden upon the inhibitory heat-centre, and actually paralyzes it.
The method in which fever is produced also becomes very evident when once the existence of an inhibitory heat-centre has been established. Any poison having the power to depress, and finally paralyze, this centre must, if it find entrance to the blood, produce fever.
The way in which this is produced is by an indirect, and not a direct, action upon the inhibitory heat-centre. The casualties of the late war proved but too abundantly that a man may be wounded in one part of the body and suffer from paralysis of voluntary motion in another part.
The way in which galvanization of a nerve, violent injuries and excessive pain depress the temperature, independently of any action upon the circulation, is now evident. An impulse simply passes up the irritated or wounded nerve, and excites this inhibitory heat-centre to increased action, and the temperature falls because the chemical movements of the body are repressed.
It would be going too far at present to assert that all fever is produced in the way spoken of. There are certain drugs which lower the temperature in the fever that follows division of the cord and consequent paralysis of the heat-centre, and which must therefore act either upon the blood, or universally upon the tissues so as to diminish their-chemical movements.
If the poison, from its inherent properties, or from its being in very small quantity, only diminishes the activity of the inhibitory heat-centre, the controlling influence is not entirely removed from the chemical movements of the body, and only slight fever results; but if the poison actually paralyzes the inhibitory nerves, a very great rise of temperature must rapidly follow the complete removal of the brake-power.
We have seen that galvanization of a nerve may excite the inhibitory centre to activity, and the peculiar persistent irritation of a local inflammation may deprive the same centre of its power of action: in the one instance a reflex inhibitory heat-centre spasm i.e., lowering of temperature is produced, and in the other a reflex inhibitory heat-centre paralysis i.e., fever results.
The experiments which have been adduced prove that there are nerves whose function it is to control the general vital chemical actions, and that the governing centre of these nerves is situated above the medulla oblongata. To this centre, whose exact location is unknown, the name of the inhibitory heat-centre has been given.
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