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Whytt mentions an instance in which tobacco became repugnant to a woman each time she conceived, but after delivery this aversion changed to almost an appetite for tobacco fumes. Panaroli mentions an instance of sickness caused by the smell of sassafras, and there is also a record of a person who fell helpless at the smell of cinnamon. Wagner had a patient who detested the odor of citron.

The active physician has usually little time nowadays to give to the older books, but it is still a valuable lesson in common sense to read, not so much the generalizations as the cases of Whytt, Willis, Sydenham, and others.

The Leyden methods of instruction were carried far and wide throughout Europe; into Edinburgh by John Rutherford, who began to teach at the Royal Infirmary in 1747, and was followed by Whytt and by Cullen; into England by William Saunders of Guy's Hospital.

The son of one of the friends of Wagner would vomit immediately after the ingestion of any substance containing honey. Bayle has mentioned a person so susceptible to honey that by a plaster of this substance placed upon the skin this untoward effect was produced. Whytt knew a woman who was made sick by the slightest bit of nutmeg.

Whytt mentions a woman of delicate constitution and great sensibility of the digestive tract in whom foods difficult of digestion provoked spasms, which were often followed by syncopes. Bayle describes a man who vomited violently after taking coffee. Wagner mentions a person in whom a most insignificant dose of manna had the same effect.

Physiological researches have led sincere investigators to the inevitable conclusion that there is subtle, refined, dynamic substance, a reality that binds up the reorganization, causes growth, vitality and motion; repairs injuries; makes up losses; overcomes and cures diseases. Von Helment called it "Archeus"; Stahl called it "Anima;" Whytt called it the "sentiment principle;" Dr.