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If we consider the knowledge positively acquired, in this short time, of the modus operandi of urari, of atropia, of physostigmin, of veratria, of casca, of strychnia, of bromide of potassium, of phosphorus, there can surely be no ground for doubting that, sooner or later, the pharmacologist will supply the physician with the means of affecting, in any desired sense, the functions of any physiological element of the body.
Kennedy at once administered the physostigmin, I thought with an air of great relief. "This is one of the rare cases in which two drugs, both highly poisonous, are definitely antagonistic," he explained. "Each, therefore, is an antidote for the other when properly administered."
It was wholly a question whether the physostigmin had been given to him quickly enough. Kennedy straightened finally, and we knew that the crisis was over. Marilyn broke down completely and had to be supported to a chair. Strong, willing arms lifted Shirley to take him to his dressing room.
Kennedy found the little vial and examined it. "Atropin!" he ejaculated. "Walter!" He turned to me. "Get some physostigmin, quick! Have Mackay drive you! It's it's life or death! Here I'll write it down! Physostigmin!" As I raced madly out and down the stairs, Mackay at my heels, I heard a woman's scream. Marilyn! Did she think him dead?
The substance isophysostigmin, found with eserin in Calabar bean, according to Ogiu, exceeds in its myotic activity the sulphate of eserin, i. e., 1/80 of a grain of the drug is equal to 1/60 of a grain of the sulphate of eserin, but it is certainly not less irritating than physostigmin, and according to Stephenson's researches, is more so, and in this sense has no superiority over the usual alkaloid.
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