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Other headaches, again, will be accompanied by a fresh, natural color and a perfectly normal and healthy distribution of the blood-supply. In short, the amount of blood in the head, whether plus or minus, has practically nothing to do with the pain, but depends solely upon the effect of the poisons producing it upon the heart and great blood-vessels.

Fact was not substituted for conjecture until about the year 1851, when the great Frenchman Claude Bernard conclusively proved that at least one chief function of the sympathetic fibrils is to cause contraction of the walls of the arterioles of the system, thus regulating the blood-supply of any given part.

Obviously, that any processes which require a full or unusually large share of blood-supply for their carrying out will be instantly stopped by the diversion of this from their secreting cells, in the wall of the stomach, in the liver, or in the capillaries of the brain, to the great muscular masses of the body, or by some strange, atavistic reflex into the so-called "abdominal pool," the portal circulation.

Cutting off this main artery, it would seem, should cut off entirely the blood-supply to the particular organ which is supplied by this vessel; and until the time of Hunter's demonstration this belief was held by most physiologists.