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Updated: May 28, 2025
The complete data of these experiments will be later reported in a monograph; here it is sufficient to state that anger, fear, injury, muscular exertion, inhalation anesthesia, strychnin, alcohol, in fact, all the stimuli which we had already found to produce histologic changes in the brain, the adrenals, and the liver-excepting bacterial toxins caused increased H-ion concentration.
In fact, the H-ion concentration of the blood in the adrenal vein was less than in the blood of any other part of the circulation. Kinetic Diseases If our conclusions are sound, then in the kinetic system we find an explanation of many diseases, and having found the explanation, we may find new methods of combating them.
In our experiments no increase in the H-ion concentration was produced by morphin or by scopolamin, no matter how deep the narcotization. In animals already narcotized by morphin the production of acid by any of the acid-producing stimuli was delayed or prevented.
One of the most noticeable immediate effects of the administration of an inhalation anesthetic is a marked increase in the rapidity and force of the respiration. The respiratory center has evidently been evolved to act with an increase of vigor which is proportional within certain limits to the increase in the H-ion concentration, whereas the centers governing the voluntary muscles are inhibited.
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