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Meanwhile Maffeo Pirovano, after being delayed on his journey by violent storms and floods, and narrowly escaping with his life from the brigands and highwaymen who infested the streets of Cologne, had at length reached Antwerp and discharged his errand.

Arrival of the Duke of Orleans at Asti The Neapolitan fleet sent against Genoa The forces of Naples repulsed at Rapallo Charles VIII. at Asti Beatrice d'Este entertains him at Annona The king's illness His visit to Vigevano and Pavia His interview with the Duke and Duchess of Milan Last illness and death of Giangaleazzo Sforza Lodovico proclaimed Duke at Milan Mission of Maffeo Pirovano to Maximilian.

Relative to its geographic distribution, Pyle states that da Silva Lima and Seixas of Bahia have reported numerous cases in Brazil, as have Figueredo, Pereira, Pirovano, Alpin, and Guimares. Toppin reports it in Pernambuco. Mr. Milton reports a case from Cairo, and Dr. Creswell at Suez, both in slaves. E. A. G. Doyle reports several cases at the Fernando Hospital, Trinidad.

Accordingly he ordered one of his most trusted agents, Maffeo Pirovano, to start the next day for Antwerp, with letters informing Maximilian and his wife of Giangaleazzo's death, and asking for the prompt despatch of ambassadors with the coveted privileges.

Lodovico joins Charles VIII. at Sarzana Suspicious rumours as to the late duke's death Piero de' Medici surrenders the six fortresses of Tuscany to Charles VIII. Lodovico retires in disgust from the camp Congratulations of all the Italian States on his accession Grief of Duchess Isabella Her return to Milan Mission of Maffeo Pirovano to Antwerp His interviews with Maximilian and Bianca Letter of Lodovico to the Bishop of Brixen Charles VIII. enters Rome His treaty with Alexander VI. and departure for Naples.

Among the many illustrious personages, religious and secular, who were present on this occasion, Fra Luca mentions "Messer Galeazzo Sforza di San Severino, my own special patron," to whom he presented the beautiful illuminated copy of his treatise, now in the Ambrosiana, the Prior of the convent of Santa Maria delle Grazie, the doctors and astrologers, Ambrogio da Rosate, Pirovano, Cusani and Marliani, and many well-known jurists, councillors, architects, and engineers, including Leonardo da Vinci, "our fellow-citizen of Florence, who, in sculpture and painting alike, justifies his name and surpasses" i.e. vince = conquers "all other masters."