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Updated: May 22, 2025
The latter not only assisted production but actually produced sufficient quantities of important drugs to tide us over the difficult period. Thus, for example, for the production of novocain the assistance of about forty university laboratories throughout the country was invoked, and they proceeded to produce the intermediates, diethylamine and ethylene-monochlor-hydrin.
These substances were converted into diethyl-amino-ethanol, and the final step, the production of novocain, was undertaken by manufacturers, including a prominent dye firm.
The Royal Society; Novocain. So serious was the situation that for some time we existed on feeble stocks. But during this period the utmost efforts were made to develop our own production. The Royal Society promptly came forward with a scheme to link up would-be producers with appropriate centres of research.
Some work had been done on this during the war for the National Health Insurance Commissioners in connection with the production of novocain. Half scale work had occurred at the works of a Midland chemical firm, and experience so gained was freely offered and used in a scheme for the large scale production of mustard gas by the co-operation of a number of big chemical manufacturers.
The patient is given a general anæsthetic, or regional anæsthesia is obtained by injections of a solution of one per cent. novocain into the line of the lateral and middle cutaneous nerves; the disinfection of the skin is carried out on the usual lines, any chemical agent being finally got rid of, however, by means of alcohol followed by saline solution.
As has been mentioned in the chapter on diagnostic principles, if the condition is so painful that the subject does not relax the parts and crepitation is masked, local anesthesia is necessary. An anesthetic solution of cocain or novocain may be applied to the metacarpal or metatarsal nerves and an entirely satisfactory examination is then possible.
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