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Updated: May 26, 2025


It is the microscopic yeast-plant which, by seizing on certain atoms of the molecule, liberates the remaining atoms in the form of carbonic-acid and alcohol, thus effecting fermentation; it is another microscopic plant a bacterium, as Devaine had christened it which in a similar way effects the destruction of organic molecules, producing the condition which we call putrefaction.

In 1850 Devaine had seen multitudes of bacteria in the blood of animals who had died of anthrax, but he did not at that time think of them as having a causal relation to the disease.

That a microscopic vegetable could cause a virulent systemic disease was an idea altogether too startling to be accepted in a day, and the generality of biologists and physicians demanded more convincing proofs than Devaine as yet was able to offer. Naturally a host of other investigators all over the world entered the field. Foremost among these was the German Dr.

In particular they led the French physician Devaine to return to some interrupted studies which he had made ten years before in reference to the animal disease called anthrax, or splenic fever, a disease that cost the farmers of Europe millions of francs annually through loss of sheep and cattle.

Robert Koch, who soon corroborated all that Devaine had observed, and carried the experiments further in the direction of the cultivation of successive generations of the bacteria in artificial media, inoculations being made from such pure cultures of the eighth generation, with the astonishing result that animals thus inoculated succumbed to the disease.

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