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A letter written in Rome by a Venetian, August 4th, merely says: "The Duke of Biseglia, Madonna Lucretia's husband, has secretly fled and gone to the Colonna in Genazzano; he deserted his wife, who has been with child for six months, and she is constantly in tears." She was in the power of her father, who, highly incensed by the prince's flight, banished Alfonso's sister Donna Sancia to Naples.

Bisceglie, formerly pronounced and written Biseglia or Biselli. Quadrata is now Corato, near Andria. Lucretia, now Duchess of Biselli, had been living since July, 1498, with a new husband, a youth of seventeen, she herself having just completed her eighteenth year.

In 1492 she was married to Giovanni Sforza, Lord of Pesaro. But in 1497 the pretensions of the Borgias had outgrown this alliance, and their public policy was inclining to relations with the Southern Courts of Italy. Accordingly she was divorced and given to Alfonso, Prince of Biseglia, a natural son of the King of Naples.

He gave her a letter to the priors of Spoleto which was as follows: DEAR SONS: Greeting and the Apostolic Blessing! We have entrusted to our beloved daughter in Christ, the noble lady, Lucretia de Borgia, Duchess of Biseglia, the office of keeper of the castle, as well as the government of our cities of Spoleto and Foligno, and of the county and district about them.

First, she was married to Giovanni Sforza, Lord of Pesaro, but differences of opinion regarding politics and the pope's desire for a still more powerful son-in-law led him to sanction Lucrezia's divorce; she was then promptly married to Alphonso, Prince of Biseglia, a natural son of the King of Naples.