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Updated: June 8, 2025


Three to five one-thousandths of a gram, or six one-hundredths of a grain, are very dangerous. More than that, the poisoning differs from most poisons in the long time that elapses between the taking of it and the first evidences of its effects. "Muscarin," Kennedy concluded, "has been chemically investigated more often than any other mushroom poison and a perfect antidote has been discovered.

Here it is growing on the same spot as the edible sorts, fed by the same soil, given sun and rain from heaven the same as they; rich and strong it is, and good to eat, save, only, that it is full of impertinent muscarin. I once thought of making up a fine old story about the toadstool, and saying I had read it in a book.

"Some poisonous Amanita got mixed with the edible mushrooms?" Kennedy answered, quickly, without taking his eyes off the line the needle was tracing: "No; this was a case of the deliberate use of the active principle itself, muscarin with the expectation that the death, if the cause was ever discovered, could easily be blamed on such a mushroom.

Atropin, or belladonna, is such a drug." For a moment I looked about at the others in the room. Had it been an accident, after all? Perhaps, if any of the others had been attacked, one might have suspected that it was. But they had not been affected at all, at least apparently. Yet there could be no doubt that it was the poisonous muscarin that had affected Mansfield.

Many years ago scientists analyzed its poisonous alkaloids and found what they called bulbosine. Later it was named muscarin, and now is sometimes known as amanitin, since it is confined to the mushrooms of the Amanita genus. "Amanitin is a wonderful and dangerous alkaloid, which is absorbed in the intestinal canal. It is extremely violent.

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