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"On opening the body, the liver-region proved to be entirely deranged; in the place where the gall-bladder should have been, a stone of the size of a pigeon's egg was found grown into the liver, and no gall-bladder now there."

The bilious vomiting and purging, that affects some people by intervals of a few weeks, is a less degree of this disease; the bile-duct is less irritable than natural, and hence the bile becomes accumulated in the gall-bladder, and hepatic ducts, till by its quantity, acrimony or viscidity, a greater degree of irritation is produced, and it is suddenly evacuated, or lastly from the absorption of the more liquid parts of the bile, the remainder becomes inspissated, and chrystallizes into masses too large to pass, and forms another kind of jaundice, where the bile-duct is not quite paralytic, or has regained its irritability.

This kind of jaundice is not generally attended with pain, neither at the extremity of the bile-duct, where it enters the duodenum, nor on the region of the gall-bladder. Mr.

This disease is attended with much pain, which at first is felt at the pit of the stomach, exactly in the centre of the body, where the bile-duct enters the duodenum; afterwards, when the size of the bile-stones increase, it is also felt on the right side, where the gall-bladder is situated.

Vieussens, the celebrated anatomist, reports an instance in which the liver weighed 20 pounds, and in his "Aphorisms," Vetter cites a similar instance. In 1811 Kraus of Germany describes a liver weighing 25 pounds; modern instances of enlarged liver are too numerous to be quoted here. Rupture of the gall-bladder, although generally followed by death, is not always fatal.

The lair of the bacilli is believed to be the gall-bladder. As to treatment, it may be broadly stated that all authorities and schools are for once practically agreed: First, that we have no known specific drug for the cure of the disease.

The latter want the gall-bladder, which all antelopes have. Another distinction is found in the horns. The deer's horns are composed of a solid bony substance, which differs from true horn. The horns of the antelope are more like those of a goat. These are the principal distinctions. In most other respects deer and antelopes are alike.

In Okyon, when a leopard is killed, its body is treated with great respect and brought into the killer's village. Messages are then sent to the neighbouring villages, and they send representatives to the village and the gall-bladder is most carefully removed from the leopard and burnt coram publico, each person whipping their hands down their arms to disavow any guilt in the affair.

A subsequent increase in the quantity of bile indicates a greater flow of bile into the gall-bladder, and this also is of service in emptying out any stagnant bile, and restoring the normal condition when this is disturbed.

But I fear such a hypothesis would not stand the test of experiment, as it might be expected to follow that, upon dissection, the contents of a negro's gall-bladder, or at least the extravasated bile, should uniformly be found black.