The iris becomes attached to the pectinate ligament and to the endothelium of Descemet's membrane. In a very few cases the closure of the angle is not complete at the apex, a small space remaining comparatively free for a long time. The adhesion of the iris to the pectinaform ligament and cornea is not uniform at all parts of the periphery; it varies in width.
This is thought to be a defect in development. The changes that occur in the tissues of the eye appear to be largely due to the stretching consequent on the more or less uniform distentions of the globe as a result of hypertension. Cornea. Fissures occur in Descemet's membrane. Anterior Chamber. This is very deep in the greater number of cases. However, this rule has many exceptions.
When it does occur it takes place in corneæ that have suffered from keratitis. The alteration is usually in the form of ectasiæ. Often, however, the enlargement of the cornea is irregular. Increase in tension may produce fissures in Descemet's membrane. These occur more frequently in the cornea that have suffered a change in shape, as in buphthalmos.