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Updated: May 26, 2025
Then he found cases in which, besides bacteria of one definite and constant form, there were others also accumulated within and around the tubular glands, of various size, some short and thick, others very fine; and be soon concluded that he had to do here with a primary invasion of pathogenic bacilli, which, as it were, prepared the tissues for the entrance of the non-pathogenic forms, just as he had observed, in the necrotic, diphtheritic changes in the intestinal mucosa and in typhoid ulcers.
These lysines are as mysterious to us as the alexines, but they neutralize the effect of the alexines and thus overcome the resistance the body offers to bacterial growth The invaders can now multiply rapidly enough to get a lasting foothold in the body and then soon produce the abnormal symptoms which we call disease Pathogenic bacteria thus differ from the non-pathogenic bacteria primarily in this power of secreting products which can neutralize the ordinary effects of the alexines, and so overcome the body's normal resistance to their parasitic life.
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