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Miyoshi Nagateru retired to Chion-in, where he committed suicide; Sumimoto fled to Awa, dying there a few months later, and Yoshitane, after brief refuge in the island of Awaji, died in Awa, in 1523. Thus, Hosokawa Takakuni found himself supreme in Kyoto, and he proceeded to appoint a shogun, without awaiting the demise of Yoshitane.

Thereupon Miyoshi Nagateru moved up from Shikoku at the head of a strong army, and, after a fierce conflict, Motochika and Sumiyuki were killed, and Sumimoto, then in his eleventh year, became chief of the Hosokawa family, receiving also the office of kwanryo. The Motochika faction, however, though defeated, were not destroyed.

Motochika, believing that Hosokawa's ultimate intention was to elevate Sumimoto to the shogunate, in which event the latter's guardian, Nagateru, would obtain a large access of power, compassed the murder of Hosokawa, the kwanryo, and proclaimed Sumiyuki head of the Hosokawa house.

Therefore he adopted three sons: the first, Sumiyuki, being the child of the regent, Fujiwara Masamoto; the second and third, Sumimoto and Takakuni, being kinsmen of his own. The first of these three was entrusted to Kasai Motochika; the last two were placed in the care of Miyoshi Nagateru. These guardians were Hosokawa's principal vassals in Shikoku, where they presently became deadly rivals.