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Thus, the furious initiative symptoms of pneumonia, of peritonitis, or erysipelas, of the exanthemata, are exaggerations of phenomena which are analogous to the phenomena accompanying physical injury and fear of physical violence.

During the heats of summer, some few persons of gross habits have, in consequence of violent exercise and excess, been seized with putrid fevers, attended with exanthemata, erisipelatous, and miliary eruptions, which commonly prove fatal: but the people in general are healthy, even those that take very little exercise: a strong presumption in favour of the climate!

In peritonitis, cholecystitis, pleurisy, arthritis, appendicitis, salpingitis, child-birth, in obstructions of the intestinal and the genito-urinary tract, in short, in those acute processes in which the local symptoms are powerful enough to govern the individual as a whole, to make him lie down and keep quiet, refuse food and possibly reject what is already in the stomach, in all these conditions there is rarely a headache, but in the diseases in which local pain is absent, such as the exanthemata, typhoid fever, and auto-intoxication, which have no dominating local disturbances to act as policemen to put the individual to bed and to make him refuse food that he may be in the most favorable position to combat the oncoming disease, in such cases in which these masterful and beneficent local influences are absent we postulate that headache has been evolved to perform this important service.

The pyogenic infections and the exanthemata constitute the great majority of infections and are the basis of the discussion which follows.

The primary, and perhaps the most striking, difference between the painless exanthemata and the painful pyogenic infections is that in the case of the exanthemata the protective response of the body is a chemical one, the formation of antibodies in the blood, which usually produce permanent immunity, while the response to the pyogenic infections is largely phagocytic.