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The fruits of his victory had hardly been gathered when death overtook him, in 1543. His sword descended, however, to a still greater leader, his son Ujiyasu, who pushed westward into Suruga; stood opposed to Kai in the north, and threatened the Uesugi in the east.

The third is Takeda of Kai, who struggled on one side with the Uesugi of Echigo and on the other with the Imagawa of Suruga. The fourth is Oda Nobunaga, who escorted the shogun to the capital. And the fifth is the great Mori family, who, after crushing the Ouchi and the Amako, finally came into collision with the armies of Oda under the leadership of Hideyoshi.

At a somewhat earlier date, Kenshin had been similarly supplicated by Murakami Yoshikiyo, whose castle was at Kuzuo in Shinano, whence he had been driven by Takeda Shingen. It thus fell out that Uesugi Kenshin had for enemies the two captains of highest renown in his era, Hojo Ujimasa and Takeda Shingen. This order of antagonism had far-reaching effects.

These septs, finding themselves so powerful, became unmanageable. Then the division of the Ashikaga into the Muromachi magnates and the Kamakura chiefs brought two sets of rulers upon the same stage, and naturally intrigue and distrust were born, so that, in the end, Muromachi was shaken by Hosokawa, and Kamakura was overthrown by Uesugi.

The first two shitsuji at Muromachi were Ko Moronao, the great general, and Uesugi Tomosada, a connexion of Takauji. Kamakura was not neglected, however.

For Kenshin's ambition was to become master of the whole Kwanto, under pretence of re-establishing the original Uesugi, but his expansion southward from Echigo was barred by Shingen in Shinano and Kai, and his expansion eastward by the Hojo in Sagami and Musashi.

Again, in the direction of Echigo and Shinano, the great captain, Uesugi Kenshin, dared not strike at Nobunaga's province without exposing himself to attack from Takeda Shingen. But Shingen was not reciprocally hampered. His potentialities were always an unknown quality.

He belonged to the Nagao, which originally stood in a relation of vassalage to the Yamanouchi branch of the Uesugi in Echigo, and his father attained an independent position.

The Tokugawa chief himself lost no time in putting his troops in motion for Yedo, where, at the head of some sixty thousand men, he arrived in August, 1600, his second in command being his third son, Hidetada. Thence he pushed rapidly northward with the intention of attacking Uesugi.

At this time Hideyoshi cemented relations of friendship with the Uesugi family of Echigo, whose potentialities had always been a subject of apprehension to Nobunaga. The powerful sept was then ruled by Kagekatsu, nephew of the celebrated Kenshin.