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Her sister, Girolama Farnese, widow of Puccio Pucci, had entered into a second marriage this time with Count Giuliano Orsini of Anguillara and had been murdered by her stepson, Giambattista of Stabbia, because, as it was alleged, she had tried to poison him. Giulia buried her deceased sister in 1504, at Bassanello.

He therefore endeavored again to set them at loggerheads, and he succeeded in attaching the Orsini to himself, which they subsequently had reason to regret. He accomplished his purpose so well that they intermarried with the Borgias; Paolo Orsini, Giambattista's brother, uniting his son Fabio with Girolama, a sister of Cardinal Giovanni Borgia the younger, September 8, 1498.

Is not that sufficient proof that his admonition of Roderigo was dictated purely by his personal affection for him? This son was publicly acknowledged and cared for by the cardinal. Seven years later in 1467 he became the father of a daughter Girolama de Borja by a spinster, whose name again does not transpire. Like Pedro Luis she too was openly acknowledged by Cardinal Roderigo.

She was also accompanied by her sister Donna Girolama, consort of the youthful Don Fabio Orsini. Madonna Adriana Orsini, another woman named Adriana, the wife of Don Francesco Colonna, and another lady of the house of Orsini, whose name is not given, also accompanied Lucretia. It is not likely, however, that the last was Giulia Farnese.

Giovanni Borgia the younger, Cardinal Ludovico, and Rodrigo, captain of the papal guard, were her brothers. Her sister Girolama, as above stated, was married to Fabio Orsini. The ceremony of Angela's betrothal took place in the Vatican in the presence of the ambassador of France.