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Updated: May 21, 2025
Back in 1858, the pioneer student of the thymus, Friedleben, declared that the size and condition of the thymus is an index to be the state of nutrition of the body. Underfeeding for four weeks will reduce it to one thirtieth the normal. It seems to act as a storage and reserve organ, affording some protection against the limitation of growth by lack of food material.
The thymus was introduced by the great classic monograph of Friedleben on the "Physiology of the Thymus," in which he mentioned the usual forgotten pioneers: Felix Plater, a Swiss physician, who in 1614 had found an enlarged thymus in an infant dying suddenly, and Restelli, an Italian, who interested himself in the effects of removal of the thymus more than ten years before.
Friedleben believed that in the young without a thymus, there occurred a softening of the bones, and general physical and mental deterioration. He started the ball rolling for a number of researches. Moritz Schiff, of Frankfort-on-the-Main, showed that excision of the thyroid gland in dogs is invariably fatal.
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