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Updated: May 21, 2025
Prudden reports the case of a girl of twenty-five who, during convalescence from variola, became paraplegic, and during this time multiple neuromata appeared. At the postmortem more than a thousand tumors were found affecting not only the peripheral branches and the sympathetic, but also the cranial nerves and the pneumogastric.
These terms are now used to include what were formerly known as "multiple neuromata," as well as certain other overgrowths related to nerves. The essential lesion is an overgrowth of the endoneural connective tissue throughout the nerves of both the cerebro-spinal and sympathetic systems.
The illustration represents a man of forty who suffered from the disease since puberty. Pressure on the eyeball had started and the native said he expected that in two years he would lose his sight. His patient was a native of Great Britain. Among neuromata, multiple neurofibroma is of considerable interest, chiefly for the extent of general involvement.
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