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The osteo-sarcoma is characterised by the formation in the tumour of bone, the medullary spaces being occupied by sarcomatous cells in place of marrow. The osteoid sarcoma is characterised by the formation of a tissue resembling bone but deficient in lime salts, and the petrifying sarcoma by the formation of calcified areas in the stroma.
In 1821 "he performed the first operation for osteo-sarcoma of the lower jaw. In 1822 he introduced his original operation for immobility of the lower jaw. He was the first surgeon who removed the lower jaw for necrosis, and the first to tie successfully the primitive iliac artery for aneurism.
The consistence of the tumour depends on the nature and amount of the stroma, and on the presence of degenerative changes. The softer medullary forms are composed almost exclusively of cells; while the harder forms such as the fibro-, chondro-, and osteo-sarcoma are provided with an abundant stroma and are relatively poor in cells.
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