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We observed that under deep morphinization the febrile response or the muscular work done was either diminished or eliminated and that the brain-cell changes were correspondingly diminished or eliminated. We found also that brain-cell changes and muscular work followed electric stimulation alone. I conclude, therefore, that the brain-cell changes are work changes.
Blood taken directly from the adrenal vein gave a positive result, but under deep morphinization the blood from the adrenal vein was negative, and under deep morphinization the foregoing adequate stimuli were negative. The one agent which was found to protect the brain against changes in the Nissl substance morphin gave a negative result in the Cannon test for adrenalin.
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