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It has been stated that iodids are of no value except in syphilitic arteriosclerosis, but iodids in small doses are stimulant to the thyroid gland, and the thyroid secretes a vasodilating substance. Therefore, the use of either iodids or thyroid would seem to be justified in many instances of high blood pressure.
Suprarenal extract, when administered, has a vaso-constricting influence, and thyroid extract a vasodilating influence; it may be surmised that within the body these glands perform similar functions. The important part played by the thyroid gland is indicated by its marked activity at the very beginning of pregnancy.
There is probably, however, no better nitrite or nitrate than nitroglycerin. While it acts but a short time, it acts effectively, and although no nitrite has vasodilating effects for any length of time from one dose, when the doses are given repeatedly and for days at a time, the blood pressure will generally be more or less reduced.
It should not be used, except if specially indicated, in broken compensation or in other myocardial weakness. Iodids: These have no immediate action. The vasorelaxation that often occurs from iodid is quite likely due to the stimulation of the thyroid gland by the iodin, and the thyroid gland secretes a vasodilating substance.
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