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Updated: June 11, 2025
In order to give a better idea of the various phases of uric acid poisoning, I have used the following illustration in some of my lectures: A man may carry a burden of fifty pounds on his shoulders without difficulty or serious discomfort. Let this correspond to the normal solving-power and carrying-capacity of the blood for uric acid.
If you increase the burden on the man's shoulders still further, beyond his individual carrying-capacity, a point will be reached when he can no longer support its weight and will throw it off entirely. This climax corresponds to the saturation point of the blood, when the limit of its acid-carrying capacity is exceeded and its acid contents are precipitated into the tissues.
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