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Updated: May 15, 2025
There are, as has been pointed out by Mott, a leading authority in this matter, five ways in which syphilis affects the brain and nervous system: by moral shock; by the effects of the poison in producing anæmia and impaired general nutrition; by causing inflammation of the membranes and tissues of the brain; by producing arterial degeneration, leading on to brain-softening, paralysis, and dementia; as a main cause of the para-syphilitic affections of general paralysis and tabes dorsalis.
In para-syphilitic lesions such as general paralysis and tabes a positive reaction is almost always present. In inherited syphilis the reaction is positive in every case. A positive reaction may be present in other diseases, for example, frambesia, trypanosomiasis, and leprosy.
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