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I believe that the two most important instillations during the twenty-four hours of the number necessary to maintain this myosis are on retiring and if possible in the very early morning, some time between two and four o'clock. Most patients can be taught to wake themselves at the proper period of time, and are little inconvenienced by this disturbance of their sleep.
But, perhaps, the author would have confessed, that his fancy was tired, and his perseverance broken; that he knew his design to be unfinished, but that, when he saw the end so near, he could no longer refuse to be at rest. Against the instillations of this frigid opiate, the heart should be secured by all the considerations which once concurred to kindle the ardour of enterprise.
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