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Greek monarchs of the Bactrian series continued masters of Oabul and Western India till about B.C. 126; no Parthian coins are found in this region; nor do the best authorities claim for Mithridates any dominion beyond the mountains which enclose on the west the valley of the Indus. By his war with Heliocles the empire of Mithridates reached its greatest extension.

Probably they had been all effected by the year B.C. 150; since there is reason to believe that about that time Mithridates found his power sufficiently established in the west to allow of his once more turning his attention eastward, and renewing his aggressions upon the Bactrian kingdom, which had passed from the rule of Eucratidas under that of his son and successor, Heliocles.

Heliocles, who was allowed by his father a quasi-royal position, obtained the full possession of the Bactrian throne by the crime of parricide. It is conjectured that he regarded with disapproval his father's tame submission to Parthian ascendency, and desired the recovery of the provinces which Eucratidas had been content to cede for the sake of peace.