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The connective-tissue framework of a nerve-trunk consists of the perineurium, or general sheath, which surrounds all the bundles; the epineurium, surrounding individual groups of bundles; and the endoneurium, a delicate connective tissue separating the individual nerve fibres. The blood vessels and lymphatics run in these connective-tissue sheaths.
The nerve fibres, although mechanically displaced and dissociated by the overgrown endoneurium, undergo no structural change except when compressed in passing through a bony canal. The disease probably originates before birth, although it may not make its appearance till adolescence or even till adult life. It is sometimes met with in several members of one family.
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