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When the kidneys become so badly diseased that they can no longer perform their function of separating from the blood the nitrogenous end-products of digestion, uraemic poisoning occurs. In this later stage of the disease the animal staggers about if moved, and finally goes down in the stall and is unable to get up. Death is usually preceded by convulsions and coma.
When this occurs, the symptoms of pain are less evident. Death occurs from uraemic poisoning and peritonitis. The outcome is less favorable in ruminants than in solipeds. Inflammation of the sheath can be readily recognized because of the local swelling.
Should the system be exposed to a chill, while in this condition, a congestion of the surface excretory vessels takes place; and practically the whole work of elimination is thrown upon the already hard-worked kidneys, frequently resulting in uraemic poisoning and death. The presence of a grain of sand in a watch will retard its movements, if not arrest them altogether.
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