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Updated: May 6, 2025
Whether a practical commercial synthesis of quinine will follow is another matter, but it is within the bounds of possibility, or perhaps even of probability. It must not be supposed that no syntheses of alkaloids have been effected as yet. By heating butyl-aldehyde with alcoholic ammonia is formed paraconine, an alkaloid isomeric with the natural conine, but differing in physiological action.
The formula of conine, C H N, shows it to be homologous with piperidine, C H N, a derivative of piperine, the alkaloid of pepper, to be spoken of later; and, just as piperidine is derived from pyridine by the action of reducing agents, so conine is probably derived from a propyl-pyridine. The artificial alkaloid paraconine, isomeric with the natural conine, will be referred to later.
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