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Leaving his vizier, Mihr-Narses, to represent him at the seat of government, he transferred his own residence to Nishapm, in the mountain region between the Persian and Kharesmian deserts, and from that convenient post of observation directed the military operations against his active enemies, making a campaign against them regularly every year from A.D. 443 to 451.

The Oxus rises from an Alpine lake, lying on the western side of the Bolor chain in lat. 37° 40', long. 73° 50'. After a rapid descent from the high elevation of the lake, during which it pursues a somewhat serpentine course, it debouches from the hills upon the plain about long. 69° 20', after receiving the river of Fyzabad, and then proceeds, first west and afterwards north-west, across the Great Kharesmian Desert to the Sea of Aral.

Hyrcania and Parthia had indeed a certain amount of protection from the Kharesmian Desert; but the upper valleys of the great streams the satrapies of Sogdiana and Bactria must have suffered considerable annoyance from such attacks. On the side of India, the Empire enjoyed a twofold security.