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Despite his efforts, Lorenzo could not prevent its development being checked during the papal-Neapolitan quarrel with Florence. That war originated in a dispute with Pope Sixtus IV, who kept Italy in a ferment during the whole duration of his pontificate, 1471-1484.
To this Sixtus retaliated by seeking the friendship of Ferrante of Naples, a move Lorenzo anticipated by forming the league between Florence, Milan, and Venice. This league thoroughly alarmed both the Pope and Ferrante, and on the latter visiting Rome in 1475 a papal-Neapolitan alliance was formed.
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