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Updated: May 3, 2025
This was supplemented a little later by Fleming's Omnis nucleus e nucleo, when still more refined methods of observation had shown that the part of the cell which always first undergoes change preparatory to new cell-formation is the all-essential nucleus. Thus the nucleus was restored to the important position which Schwann and Schleiden had given it, but with greatly altered significance.
Not until the last quarter of the nineteenth century was it settled that the nucleus of the cell is also a supremely important part; but finally in 1882 Flemming was able to extend Virchow's aphorism to the nucleus also: omnis nucleus e nucleo.
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