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The four chief among them were Antigonus, Ptolemy, Lysimachus, and Seleucus. Antipater was now dead, but his son Cassander succeeded to his power in Macedonia and Greece. Seleucus and Lysimachus defeat Antigonus at Ipsus. Antigonus is killed in the battle. Seleucus, the last of Alexander's captains, is assassinated. Of all Alexander's successors, Seleucus had formed the most powerful empire.

When the great struggle came between the confederate monarchs and the aspirant after universal dominion, it placed him on the side of the allies. By the terms of the agreement made after Ipsus, Seleucus was recognized as monarch of all the Greek conquests in Asia, with the sole exceptions of Lower Syria and Asia Minor.

The second capital was at least as conveniently placed as the first, and would have served equally well as a centre from which to govern the Empire. But after Ipsus a further change was made a change that was injudicious in the extreme.

Antioch arose in extraordinary beauty and magnificence during the first few years that succeeded Ipsus, and Seleucus in a short time made it his ordinary residence.

The unfortunate battle at Ipsus brought him as a hostage to Alexandria, to the court of the founder of the Lagid dynasty, where by his daring and downright character, and his soldierly spirit thoroughly despising everything that was not military, he attracted the attention of the politic king Ptolemy no less than he attracted the notice of the royal ladies by his manly beauty, which was not impaired by his wild look and stately tread.

He then went to Demetrius, who had married his elder sister, and fought under him at the battle of Ipsus; after which Demetrius sent him as a hostage to Alexandria, and his grace and spirit made him so great a favourite with Ptolemy that he gave him his step-daughter Berenice in marriage, and helped him to raise an army with which he recovered his kingdom of Epirus.

The struggle for power which broke out almost immediately after his death among the successors of Alexander may be regarded as having been brought to a close by the battle of Ipsus. The period of fermentation was then concluded, and something like a settled condition of things brought about. Asia Minor, the kingdom of Lysimachus, had indeed less of unity than the other three states.

"In two hours we were in our saddles again, pushing on as if for our very lives, changing horses at every station, and turning night into day. "We were near Ipsus, when I began to feel violent pains in the head and limbs. I was ashamed to say anything about it and kept upright on my saddle, until we had to take fresh horses at Bagis.

In the great battle of Ipsus, in which all the successors of Alexander the Great took part, Pyrrhus, while yet a youth, served with the forces of Demetrius, routed those who opposed him, and gained great distinction. He did not desert Demetrius after his defeat, but was entrusted with the care of those cities which Demetrius possessed in Greece, and kept them faithful to his cause.

Vincent supposes that he may have lost his life at the battle of Ipsus, where Antigonus fell: or, after the battle, by command of the four kings who obtained the victory. Previous to his grand expedition, it appears that he was a native of Crete, and enrolled a citizen of Amphipolis, it is supposed, at the time when Philip intended to form there a mart for his conquests in Thrace.