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The notion with regard to the mode in which "immunity" was produced by either the Montacutian or Jennerian inoculation was, even after the general knowledge of microbes as the living contagion of disease had been arrived at, that the mild attack due to inoculation "used up" something in the blood in fact, exhausted the soil, so that the infective matter or microbe could no longer flourish in the blood.

Arthroplasty is most successful in ankylosis following upon injury; when the ankylosis results from some infective condition such as tuberculosis or gonorrhœa, it is liable to result in failure either because of a fresh outbreak of the infection or because the ankylosis recurs.

Early tertiary lesions may be infective, and the disease may be transmitted by the discharges from them; but the later the lesions the less is the risk of their containing an infective virus. The most prominent feature of tertiary syphilis consists in the formation of granulation tissue, and this takes place on a scale considerably larger than that observed in lesions of the secondary period.

Ce n'est rien; papa dit que c'est la santé des enfants"! Parasitic worms of various kinds, though they often cause disease and death, are accepted and tolerated even by the most refined and luxurious, who risk infection rather than submit to the precaution of abstention from raw vegetables and fruits, or to the expenditure of trouble in cleansing those nests of infective germs.

#Clinical Aspects of Inflammation.# It must clearly be understood that inflammation is not to be looked upon as a disease in itself, but rather as an evidence of some infective process going on in the tissues in which it occurs, and of an effort on the part of these tissues to overcome the invading organisms and their products.

The counteraction of the toxæmia and the treatment of the bloodless state, are carried out on the usual lines. #Hæmorrhage of Toxic Origin.# Mention must also be made of hæmorrhages which depend upon infective or toxic conditions and in which no gross lesion of the vessels can be discovered.

If there is evidence that the articulation contains infective material, it is washed out with copious quantities of peroxide of hydrogen usually as much as six or eight ounces. This is followed by injection of an ounce or two of tincture of iodin. Even though the joint appears to be clean some tincture of iodin is used, as it checks the secretion of synovia and is, in every way, beneficial.

In hysteria, in contrast to the types previously described, the infective element may be completely absent. Except in some special features of minor importance the symptoms of hysteria do not differ from those of adults, and, as in adult age, the condition of hysteria may be present although the physical development may be perfect.

Occlusion of the inferior vena cava as a result of infective thrombosis is a well-known condition, the thrombosis extending into the main trunk from some of its tributaries, either from the femoral or iliac veins below or from the hepatic veins above. Portions of the softened thrombus are liable to become detached and to enter the circulating blood, in which they are carried as emboli.

It is often difficult to decide when acute endocarditis has developed; but with the knowledge that the endocardium often becomes inflamed during almost any of the acute infections, the physician should repeatedly examine the heart for murmurs, for muffled closure of the valves, or for other evidences of endocarditis or myocarditis during the acute infective process.