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#Healing by Primary Union.# The most favourable conditions for the progress of the reparative process are to be found in a clean-cut wound of the integument, which is uncomplicated by loss of tissue, by the presence of foreign substances, or by infection with disease-producing micro-organisms, and its edges are in contact.

The following exciting causes may be mentioned: Sudden changes in ration; feeding too much green feed or grain; feeding frozen or decomposed feeds; drinking ice-cold water; and violent exercise or work that the animal is not accustomed to, immediately after feeding are the common disease-producing factors.

Moreover, the most virulently malarious region is a safe place of residence for human beings, provided they protect themselves absolutely against the bite of the mosquito. This has been strikingly demonstrated in the case of the Roman Campagna. From the disease-producing animal parasites we come now to those that are believed to be of vegetable nature.

The disease-producing organisms are present in great numbers in the nerve-tissue and saliva. The period of incubation varies from a few days to several months. It is usually from ten to seventy days. The symptoms differ in the different species. There are two forms of the disease: the furious and the dumb. The former is more common. In the dog, the symptoms may be divided into three stages.

Every one is familiar with the great amount of misery which is caused, temporarily at least, by such calamities. Again, certain things in the organic environment, particularly in the way of disease-producing bacteria, are also productive of much poverty.

Careful examinations have shown that under normal conditions, which of course include pregnancy, disease-producing bacteria are absent from the vagina; in this respect the vagina is even cleaner than the skin, for disease-producing bacteria are present on the surface of the body.

Originally one who was believed by himself and others to have power over demons the mystery-man or medicine-man using coercive methods to expel disease-producing spirits, stood in the place of doctor; and when his appliances, at first supposed to act supernaturally, came to be understood as acting naturally, his office eventually lost its priestly character altogether: the resulting physician class, originally uniform, eventually dividing into distinguishable subclasses while acquiring a definite embodiment.

With the exception of the special disease-producing germs, the most common exciting causes are faulty food and faulty methods of feeding. The following predisposing causes of disease may be mentioned: Age is an important factor in the production of disease. Young and immature animals are more prone to attacks of infectious diseases than are old and mature animals.