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The monks and ecclesiastics were supposed to be most likely to discover the secret process, since "they were such good artists in transubstantiating bread and wine." In Germany the emperors Maximilian I., Rudolf II., and Frederick II. gave considerable attention to the search, and the example they set was followed by thousands of their subjects.

The primitive disciples were very frequent in administering the holy sacrament, breaking bread from house to house; yet should they be asked of the Terminus a quo and the Terminus ad quern, the nature of transubstantiation? the manner how one body can be in several places at the same time? the difference betwixt the several attributes of Christ in heaven, on the cross, and in the consecrated bread? what time is required for the transubstantiating the bread into flesh? how it can be done by a short sentence pronounced by the priest, which sentence is a species of discreet quantity, that has no permanent punctum?

Prinn, in his "Aurum Reginae," observes, as a note to this passage, that the King's reason for granting this patent to ecclesiastics was, that they were such good artists in transubstantiating bread and wine in the Eucharist, and therefore the more likely to be able to effect the transmutation of baser metals into better.