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Marshall and those other gentlemen who have obligingly presented me with the result of their inoculations; but, as they all agree in the same point as that given in the above communication, namely, the security of the patient from the effects of the smallpox after the cow-pox, their perusal, I presume, would afford us no satisfaction that has not been amply given already.

After a certain course of this treatment it is found that a portion of blood serum of the animal so treated will act in a curative way if injected into the blood of another animal, or a human patient, suffering with diphtheria. In other words, according to theory, an antitoxine has been developed in the system of the animal subjected to the progressive inoculations of the diphtheria toxine. In Dr.

It was reprinted seven times within a year, and an eighth edition appeased in 1722. Lady Mary obtained permission, in 1721, to experiment on seven condemned criminals. Mead supervised the inoculations, and all recovered. In the following year two members of the royal family underwent the operation successfully. Thereafter, it became, in most circles, fashionable.

At present the inoculation mania has reached the pitch of proposing no less than four separate inoculations: revaccination, typhoid, cholera, and Sir Almroth's last staggerer inoculation against wounds! When the War Office and its medical advisers have been successfully inoculated against political lunacy, it will be time enough to discuss such extravagances.

I had previously demonstrated by repeated experiments that inoculations of yellow fever blood into lower animals dogs, rabbits, guinea pigs give a negative result, but this negative result might well be because these animals were not susceptible to the disease and could not be accepted as showing that the germ of yellow fever was not present in the blood.

Only the adult vibrios disappear, burn up, and lose their virulence in contact with air: the germ corpuscles, under these conditions, remain always ready for new cultures, and for new inoculations. All this however does not do away with the difficulty of understanding how septic germs can exist on the surface of objects, floating in the air and in water. Where can these corpuscles originate?

Several of these animals had been inoculated several times before any symptoms showed themselves, while in others, on the contrary, once was sufficient. It appears that in a state of doubtful rabies, one or two accidental or artificial inoculations are not sufficient to create a negative proof of its existence.

Particular occurrences I shall, of course, detail. Some of my correspondents have mentioned the appearance of smallpox-like eruptions at the commencement of their inoculations; but in these cases the matter was derived from the original stock at the Smallpox Hospital. I have myself inoculated a very considerable number from the matter produced by Dr.

But in view of the fact that this case occurred in the city of Havana, where yellow fever is endemic, and of the eighty-six negative results from similar inoculations, the inference seemed justified that in this case the disease was contracted in some other way than as a result of the so-called "mosquito inoculation."

And this view was accepted as the explanation of the "immunity" to the anthrax disease conferred on cattle and sheep by Pasteur's inoculations of weakened, but still actively growing, cultures of the anthrax bacillus.