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This monarch looked on Simonetta as a traitorous villain who had taken advantage of Bona's weakness to usurp the supreme power in Milan, and wrote to King Louis XI, begging him to come to his kinswoman's help and assist in restoring the Duke of Bari and his brother to their rights.

But the Moro, fearing the effect of Bona's presence at the French court, courteously declined Charles's invitation, alleging as an excuse the fact that both Bona's daughter-in-law, the Duchess Isabella, and her young sister-in-law, his own wife Beatrice, were expecting similar events early in the next year, while her daughter Bianca was of marriageable age and needed her mother's protection.

An attempt was made by Duchess Bona's confessor to assassinate him on the steps of Saint Ambrogio at Christmas, 1485, but fortunately failed, because that day Lodovico entered the church by a side door to avoid the crowd.

They sent messengers to Lodovico, imperiously demanding his summary punishment, and declaring that they would never lay down their arms until he and his confederates were imprisoned. After some delay, Lodovico yielded to their demand; Bona's faithful secretary was arrested and sent to Pavia with his brother, while the fickle populace sacked their houses.

This popular poet and polished cavalier was a great favourite, not only with Beatrice and her husband, but with Galeazzo di Sanseverino, the Marchesino Stanga, and all the chief personages at court. Born in 1461 of noble Milanese parents, he married Cecilia, daughter of Cecco Simonetta, Duchess Bona's ill-fated minister, and was advanced to the dignity of Eques Auratus and ducal councillor.

Messer Ambrogio da Urbino began to give Isabella dancing lessons almost as soon as she could walk. Later on a certain Messer Lorenzo Lavagnolo, who had taught Elizabeth and Maddalena Gonzaga, the young sisters of the Marquis of Mantua, and had afterwards been sent to the court of Milan to teach Duchess Bona's daughters, came to Ferrara.

Filippo Eustachio, captain of the Castello of Milan, a brave and honest man, Corio tells us, who had refused to yield up the keys of the Rocca to Bona's minion, but whose brothers had been implicated in the plot against Lodovico's life, was one day arrested by the duke's orders, and imprisoned at Abbiategrasso; he was afterwards released, no evidence of his guilt being produced, but his post was filled by one of the Moro's servants.

The Pope does not seem to have returned a direct answer to this touching prayer, but he took advantage of Bona's present mood to hurry on the marriage of Caterina Sforza, the duke's natural daughter, with his own nephew, Girolamo Riario, which had been arranged by Galeazzo, and which took place in the following April.