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He was, however, pronounced ineligible, as the Adelantado had no acknowledged, and certainly no legitimate, offspring. Baldassar, or Balthazar, Colombo, of the house of Cuccaro and Conzano, in the dukedom of Montferrat, in Piedmont, was an active and persevering claimant. He came from Italy into Spain, where he devoted himself for many years to the prosecution of this suit.
Her relations with the house of Urbino were no less pleasant, and they continued so even after the death of Guidobaldo in April, 1508, for his successor was Francesco Maria della Rovere, son-in-law of Isabella Gonzaga. She was frequently visited by these princes, and she enjoyed the friendship of a number of remarkable men Baldassar Castiglione, Ottaviano Fregoso, Aldus Manutius, and Bembo.
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