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Besides the small amount of blood pressure-raising substance secreted by the hypophysis cerebri. it has not been shown that any other gland of the body furnishes vasopressor substance except the suprarenals. Atropin: When there is great cardiac weakness, atropin may be used to advantage. The dose is from 1/200 to 1/150 grain hypodermically, not repeated in many hours.
Therefore a subsecretion of the thyroid predisposes to arteriosclerosis, and increased secretion of the suprarenals predisposes to arteriosclerosis, the thyroid furnishing vasodilator substance and the suprarenals vasopressor substance to the blood. Furthermore. if these secretions are abnormal, protein metabolism is more or less disturbed.
The hypodermic administration of epinephrin solutions, 1:10,000, or solutions of pituitary extract, 1:10,000, should be considered; they are often valuable. If the shock occurs in ether or chloroform anesthesia, the vasopressor stimulating effect of inhalations of carbon dioxid gas may be considered, as advised by Henderson."
At this time of life the thyroid is disturbed, and often, especially if weight is added, it is not secreting sufficiently. Whether, with the polyglandular disturbance of the menopause the suprarenals are excited and hypersecreting, or whether they are simply relatively secreting more vasopressor substance than is combated by the vasodilator substance from the thyroid, cannot be determined.
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